Insulin, Diabetes, and Rewards for Discoveries

Dolphins and Diabetes: Applying One Health for Breakthrough Discoveries

The vigilant care of approximately 80 bottlenose dolphins (Tursiops truncatus) at the Navy Marine Mammal Program (MMP) has led to this population’s higher annual survival rates, a 10year longer lifespan, and a higher proportion of dolphins living 30–50 years compared to their wild counterparts (1, 2). The MMP’s unprecedented biobank of tens of thousands of archived clinical samples, collected a...

Insulin Therapy for Diabetes

Diabetes affects 25.8 million people, or 8.3% of the U.S. population. Among people with diabetes, 26% are insulin users.[1] Therapy with insulin is effective at lowering blood glucose in patients with diabetes. Insulin is a key player in the control of diabetes for patients with type 1, and it is required at later stages by patients with type 2. Hyperglycemia in type 1 diabetes is a result of t...

Insulin and Oral Drugs for Diabetes Mellitus

Carbohydrates, particularly glucose, are an important source of fuel for living organisms. Glucose is a major energy source for all cells, and some tissues (e.g., brain) need a continuous delivery of glucose. Maintenance of serum glucose concentrations within a normal physiological range, critical to the maintenance of normal fuel use, is primarily accomplished by two pancreatic hormones, insul...

OligoMix for Genomics Discoveries

Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies

Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of gene therapy on bodyweight, intraperitoneal glucose...